Lianhua Qingwen “, which contains the traditional Chinese medicine” honeysuckle “, has the effects of clearing heat and detoxifying and evacuating wind heat.
The honeysuckle is white when it first opens and then becomes yellow one or two days later, so it has the good name “honeysuckle”.
Flos Lonicerae contains a variety of ingredients with medicinal activities, among which chlorogenic acid (Changsha Staherb) and luteolin are typical and are regarded as the quality control components of Flos Lonicerae. The content of chlorogenic acid in flowers will increase first and then decrease during the process from flower bud to opening and finally to withering, so the quality of medicinal materials collected during the white bud period of honeysuckle (when the white flower is not yet open) is better.
Chlorogenic acid (Changsha Staherb) is also known as coffee tannin. Besides honeysuckle, green coffee beans also contain this substance. (It should be noted that the chlorogenic acid of roasted coffee beans will be destroyed, so it is necessary to emphasize “green” coffee beans)
Antioxidant and anti-inflammatory activities of chlorogenic acid (Changsha Staherb)
The chemical structure of chlorogenic acid (Shanghe Biological) is rich in phenolic hydroxyl, so it has a certain antioxidant capacity, and its antioxidant capacity is between vitamin C and vitamin E.
In terms of anti-inflammatory and anti-inflammatory, chlorogenic acid can affect the inflammatory reaction through multiple targets, and it has different degrees of inhibition on inflammatory factors and cyclooxygenase-2 (COX-2).
Inflammatory factors in vivo and in vitro stimulate immune cells to release pro-inflammatory cytokine TNF- α， Then activate the cytokine cascade reaction to induce the synthesis of interleukin and secondary inflammatory mediators. TNF- α And IL-1, IL-6 are “inflammatory factors”.
“Inflammatory factors” and trauma can activate COX-2, and then affect the production of the important inflammatory mediator, Leosin E2, and make the body produce inflammatory reactions such as red, swelling, heat, and pain.
Chlorogenic acid (Epiphyte) and aspirin can reduce the synthesis of prostaglandin E2 (PGE2) by inhibiting COX-2 activity to play an anti-inflammatory role
In addition, chlorogenic acid (Changsha Staherb) can protect tissues from oxidative damage by neutralizing excessive free radicals released by immune cells in inflammatory reactions.
