Cerebrovascular disease is one of the most important causes of death for human beings at present, and is the first cause of disability. About 70% of them are ischemic cerebrovascular diseases. Ischemic brain injury is a multi-factor, multi-mechanism and multi-link malignant cascade reaction process, and the neurotoxicity of excitatory amino acids, calcium overload, damage of free radicals and inflammatory factors, and apoptosis of nerve cells are the central links of this injury process.
Magnolol (magnolol 1) is one of the main active ingredients extracted from Magnolia officinalis. In recent years, many studies have shown that magnolol has a protective effect on cerebral ischemia, can reduce the area of cerebellar infarction, reduce brain water content and reduce brain tissue necrosis.