Pharmacological effects of magnolol Changsha Staherb
Magnolol is a biphenyl phenol compound, which is the main active ingredient of Magnolia officinalis. Magnolol was first isolated from Japanese magnolia officinalis in 1930. Magnolol is a brown to white fine powder with aromatic odor, strong irritation and slight bitterness. The monomer is colorless acicular crystal (water) with a melting point of 102 ℃. Soluble in benzene, ether, chloroform, acetone and common organic solvents. It is difficult to dissolve in water, but it is easy to dissolve in dilute caustic soda solution to obtain sodium salt. Magnolol has antibacterial, anti-inflammatory, antioxidant, anti-tumor and other effects, and can also relieve muscle tension and relax muscle.
(1) Antibacterial effect
Magnolol has obvious antibacterial effect. The minimum inhibitory concentration of magnolol against Candida, Microsporus, Tinea minor, Aspergillus niger, Cryptococcus neoformans and Candida albicans, and the minimum inhibitory concentration against Bacillus subtilis and Mycobacterium smegmatis. Magnolol has the effect of killing oral bacteria and eliminating halitosis, and has become one of the main components of menthol and chewing gum.
(2) Anti inflammatory effect
Magnolol can inhibit lymphocyte budding, mouse ear swelling, reduce the permeability of capillary wall at the inflammatory site, inhibit leukocyte migration and fiber tissue proliferation in a dose dependent manner. It can also change the cytokine pattern of inflammation related diseases, reduce inflammatory factors, and increase the production of anti-inflammatory factors. We found that the concentration of TNF-1 in plasma and tissues increased during hemorrhagic shock, while IL, the representative of anti-inflammatory factor, did not change in organs and tissues. Magnolol can reduce the concentration of the former in the lung and increase the concentration of the latter in the lung.
The anti-inflammatory effect of magnolol may be related to the inhibition of AA metabolic pathway and the inhibition of intracellular lysosome release. The formation of superoxide anion in rat neutrophils was determined by microplate method and fluorescence colorimetry The release of glucosidase and lysozyme. The results showed that free radicals in neutrophils reduced the concentration of superoxide anion production by 1-1009M/L, and significantly inhibited the release of p glucosidase and lysozyme to activate neutrophils when the concentration was greater than 109M/L. In addition, free radicals could attenuate the sepsis caused by gastroenteritis.
Magnolia officinalis extract 5-98% Changsha Staherb